2009 Program
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Sunday, March 1
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5:30-9:00
BC/AB/Yukon
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Poster set-up
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5:30-9:00
Manitoba Room
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Registration and Welcome Reception
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6:00-6:15
Manitoba Room
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Welcome Remarks:
Neil Cashman, PrioNet Canada, and Kevin Keough, Alberta Prion Research Institute
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6:15-6:30
Manitoba Room
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Welcome Address:
Marvin Fritzler, Alberta Science and Research Authority
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Monday, March 2
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7:00-8:00
Ballroom N/W Foyer
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Breakfast buffet
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8:00-8:10
Ballroom
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Welcome:
Kevin Keough, Alberta Prion Research Institute
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8:10-9:00
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Opening Plenary:
An Historical Perspective on Efforts to Treat Transmissible Spongiform Encephalopathy
Paul Brown
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9:00-11:45
Ballroom
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Theme Session: Prevention and Mitigation
Chair: Daniel Krewski, University of Ottawa
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9:00-9:40
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Guest Speaker:
Review of UK actions to prevent secondary transmission of vCJD
Robert Will, Western General Hospital
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9:40-10:10
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Break – North Foyer
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10:10-10:35
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Experimental Challenge of Cattle with H-type and L-type Atypical BSE
Anne Buschmann, Friedrich-Loeffler-Institut
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10:35-10:50
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HQP Oral Presentation Award:
Targeted Delivery of Small Regulatory RNAs to the Brain using a Peptide Derived from Rabies Virus Glycoprotein
Amrit Singh, University of Manitoba
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10:50-11:15
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Characterization of a BSE Biomarker
David Knox, Public Health Agency of Canada
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11:15-11:40
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Molecular Characterization of BSE in Canada
Jianmin Yang, Agriculture and Agri-Food Canada / Canadian Food Inspection Agency
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11:45-1:45
Ballroom
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Poster Session
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11:45-12:45
Ballroom
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Lunch - North Foyer
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1:45-3:15
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Concurrent Workshops
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Chancellor
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Project Management – A Team Approach
Gary Robinson, EM Sciences Ltd.
Creativity, teamwork, collaboration, and freedom to adapt to the data are essential in complex research projects. Traditional project management control practices work against all of these factors, whereas a team approach to planning and managing projects enables them. This workshop presents well-tested principles and practices that provide the right balance of teamwork, autonomy and control.
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Turner Valley
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Bioinformatics
David Wishart, University of Alberta
This workshop will explore the potential applications of bioinformatics tools and resources to prion research. Topics to be discussed include: 1) "HelpDesk" resources
2) Protein interaction analysis
3) Gene expression analysis
4) Informatics tools for proteins structure/function/stability analysis Attendees are invited to share ideas, experiences and requests.
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Leduc
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Principles of Risk Management Decision Making
Daniel Krewski, University of Ottawa
There exist a range of regulatory, economic, advisory, community based, and technological options for controlling risks to population health. This workshop will examine risk management decision making options, along with principles for choosing among those options in order to achieve the best possible risk management policies and strategies. The use of these principles will be illustrated through their application to prion disease risk management.
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3:15-3:45
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Break – North Foyer
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3:45-5:30
Ballroom
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Theme Session: Environment
Chair: Bob Hills, Health Canada
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3:45-4:25
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Guest Speaker:
Transmission and Pathogenesis of Chronic Wasting Disease (CWD) in Cervid and Non-Cervid Species
Edward A. Hoover, Colorado State University
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4:25-4:50
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Environmental Reservoir of CWD Infectivity
Judd Aiken, University of Alberta
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4:50-5:15
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Prion Alleles influence Disease Progression in Orally infected White-tailed Deer
Debbie McKenzie, University of Alberta
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5:15-5:30
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HQP Oral Presentation Award:
Using Population Genetics as a Tool to Assess the Relative Risk of Chronic Wasting Disease Spread
Catherine Cullingham, University of Alberta
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5:30
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Wrap-up
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Tuesday, March 3
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7:00-8:00
Ballroom
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Breakfast buffet – North Foyer
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8:00-8:10
Ballroom
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Welcome:
Neil Cashman, PrioNet Canada
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8:10-9:00
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Opening Plenary:
Prion Infection - seeded fibrillization or more?
Detlev Riesner, Heinrich-Heine-Universität Düsseldorf
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9:00-12:00
Ballroom
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Theme Session: Pathobiology and Chemistry
Chair: David Wishart, University of Alberta
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9:00-9:35
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Guest Speaker:
Phosphorylation of Prion Protein at Serine 43 induces prion protein conformational change
Andréa LeBlanc, McGill University
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9:35-10:05
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Break
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10:05-10:30
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Temporal Changes in Gene Expression in Micro-dissected Degenerating Neurons of the Hippocampus and Cerebellum in Mouse Scrapie
Stephanie Booth, Public Health Agency of Canada
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10:30-10:45
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HQP Oral Presentation Award:
The Primary Brain Cholesterol Homeostasis Gene, CYP46A1, is Post-Transcriptionally Regulated by Prion Disease Specific microRNAs (miRNAs)
Reuben Saba, University of Manitoba
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10:45-11:10
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Prion Protein Trafficking
Marco Prado, University of Western Ontario
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11:10-11:25
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HQP Oral Presentation Award:
Mechanisms of Axonal Transport of the Mammalian Prion Protein and Prions
Sandra Encalada, University of California, San Diego
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11:30-1:30
Ballroom
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Poster Session
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11:30-12:30
Ballroom
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Lunch – North Foyer
Address: Honorable Doug Horner, Minister of Advanced Education and Technology, Government of Alberta
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1:30-2:30
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Panels
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Devonian (main floor)
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Prion safety: disposal and risks
Moderator: Daniel Krewski, University of Ottawa
Participants:
Mike Belosevic, University of Alberta
Larry Schonberger, U.S. Centers for Disease Control and Prevention
Robert Somerville, University of Edinburgh
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Ballroom
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Atypical TSEs: a cause for concern?
Moderator: Neil Cashman, University of British Columbia
Participants:
Aru Balachandran, Canadian Food Inspection Agency
Stephanie Czub, Canadian Food Inspection Agency
Jean-Philippe Deslys, France Atomic Energy Commission
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2:35-5:20
Ballroom
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Theme Session: Pathobiology and Chemistry (continued)
Chair: David Wishart, University of Alberta
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2:35-3:05
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Guest Speaker:
Computational Studies of Prion Protein Conformational Changes
Valerie Daggett, University of Washington
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3:05-3:20
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HQP Oral Presentation Award:
New genetic mouse models of prion disease
Walker Jackson, Whitehead Institute for Biomedical Research
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3:20-3:45
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Break
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3:45-4:10
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Induction of PrPC Misfolding by Immunological Mimicry of PrPC-PrPSc Interactions
Neil Cashman, University of British Columbia
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4:10-4:25
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HQP Oral Presentation Award:
Energetic Modelling of the Prion Protein: Identification of Unfolding and Misfolding Foci
Will Guest, University of British Columbia
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4:25-4:50
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Folding Intermediates of the Prion Protein and Prion Disease Susceptibility
Avi Chakrabartty, University of Toronto
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4:50-5:15
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Mass Spectrometric Approaches to Detecting and Quantifying Prions
Christopher Silva, United States Department of Agriculture
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5:15
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Wrap-up
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6:00-7:15
North Foyer
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Networking Reception
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7:15-9:15
Manitoba/
Saskatchewan
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Banquet Dinner and Student and Post-doctoral Fellow Poster Awards Presentation
Closing Address:
Alain Beaudet, Canadian Institutes of Health Research
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